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PRE- CLINICAL CHARACTERIZATION OF ATORVASTATIN & MILNACIPRAN COMBINATION FOR THE TREATMENT OF NEUROPATHIC PAIN
Sachin Kumar Bansal1, Dr. Savithiri Shivakumar2
Abstract:
Neuropathic pain, a complex and chronic pain condition resulting from damage to the nervous system, presents significant challenges in clinical management. Current therapeutic approaches often involve a combination of pharmacological and non-pharmacological strategies. This research explores the pre-clinical characterization of a novel therapeutic combination of atorvastatin, a statin with neuroprotective properties, and milnacipran, a dual serotonin-norepinephrine reuptake inhibitor, for the treatment of neuropathic pain. The study aims to evaluate this combination therapy's efficacy, safety, and underlying mechanisms in animal models to provide a foundation for future clinical investigations.