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A STUDY ON FORMULATION AND EVALUATION OF BUCCAL FILMS OF NATEGLINIDE
Tarunika Uniyal Dr. Shivanand M.Patil
Abstract:
Numerous illnesses, whether acute or chronic, are typically treated with the aid of a drug delivery system and particular dose forms. The oral route is one of the several delivery methods for medication that is ideal and preferred by patients. For some medications, the oral route causes issues. Several factors, including the location of the enzymes in the GI fluids, the pH of the GIT, and the enzymes attached to the GIT membranes, may contribute to bioavailability issues. In some instances, the mechanism or the route of administration can be changed to address drug-related issues. The development of new drug molecules entities to the unique delivery method of already existing drug molecules up to certain extending changes their therapeutic efficacy, patient protection, and prevent unwanted consequences were the key study areas. Using powerful pharmaceuticals is one of the much technological advancement that is essential to a healthy living. Notwithstanding its safety and pharmacological efficacy, the idea of a dosage form in which a medicine is incorporated is effectively evolving. Drug delivery systems have been designed using a variety of scientific technologies. Due to its superior accessibility, pleasant dosage administration, and patient compliance for non-invasive medication delivery, oral drug administration is significant and frequently employed. Oral dosing forms have some drawbacks, including uneven medication absorption, brief stomach residence duration, and partial drug release. To get over these restrictions, a lot of focus has recently been placed on adapting oral dose forms to survive in diverse GIT environments. Although the relationship between medication administration and its pharmacological effect is a complex parameter, choosing and formulating the optimum dosage form is an essential step in the drug development process. Each drug response is affected by a number of intrinsic and extrinsic factors, including product bioavailability (drug absorption rate), pharmacokinetics, and the specific concentration-effect connection.
