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OPTIMIZATION OF SOLUBILITY ENHANCEMENT METHODS FOR THE POORLY WATER-SOLUBLE DRUG ITRACONAZOLE
Neetu Verma1 , Dr. K Saravanan (Professor)2
Abstract:
Itraconazole was characterized prior to its formulation by means of analyses such as its saturation
solubility, ultraviolet (UV) spectroscopy, melting point, partition coefficient, effect of pH, Fourier
transform infrared (FTIR), and solubility profile in a number of buffer solutions. To determine the
absorption maxima, a solution containing 10 g/ml of Itraconazole in distilled water with 0.75 %
SLS, acetate buffer of “pH 1.2, and phosphate buffer of pH 6.8” and 7.4 was scanned independently
between the wavelengths 200-400 nm with a UV/Vis double beam spectrophotometer for
quantitative estimation calibration curves. The applicability of the method was confirmed by
correlation coefficients between 0.99 and 1.